hello Lisa,
welcome to the forum.
i failed on Methotrexate and Hydroxycholorquine combination .. had to give it 18 months though.
had a long 6 month wait while my PCT approved my funding for Humira, and have now been on it 2 years. it has been magic for me. i am just stopping the Hydroxy and only take 10mg Methotrexate along with the Humira now.
i don't take any painkillers or steroids,
it's very trial and error to get the right meds,
i have a Humira Blog somewhere on here, i might update it for anyone else starting out on it.
best wishes to your Mum
Suzanne